news & publications

Sphingosine-1-phosphate (S1P)

M. Hanson, C. Roth, E. Jo, M. Griffith, F. Scott, G. Reinhart, H. Desale, B. Clemons, S. Cahalan, S. Schuerer, M. G. Sanna , G. W. Han, P. Kuhn, H. Rosen, R. Stevens. "Crystal Structure of a Lipid G Protein-Coupled Receptor". Science. 335, 851-855 (2012).
Cahalan, S.M., Gonzalez-Cabrera, P.J., Sarkisyan, G., Nguyen, N., Schaeffer, M.T, Huang, L., Yeager, A. , Clemons, B. Scott, F. , and Rosen, H. "Actions of a picomolar short-acting S1P1 agonist in S1P1-eGFP knock-in mice". Nat. Chem. Biol. 7, 254-256 (2011).
Rosen, H., P. Gozalez-Cabrera, M. Sanna, and S. Brown. "Sphingosine 1-phosphate receptor signaling". Ann. Rev. Biochem. 78, 743-763 (2009).
Marsolais, D., and H. Rosen. "Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules" Nat. Rev. Drug Discov. 8, 297-307 (2009).
Rosen, H., P. Gonzalez-Cabrera, D. Marsolais, S. Cahalan, A.S. Don, and M.G. Sanna. "Modulating tone: the overture of S1P receptor immunotherapeutics" Immunol. Rev. 223, 221-235 (2008).
Gonzalez-Cabrera, P.J., E. Jo, M.G. Sanna, S. Brown, N. Leaf, D. Marsolais, M.T. Schaeffer, J. Chapman, M. Cameron, M. Guerrero, E. Roberts, and H. Rosen. 2008. "Full pharmacological efficacy of a novel S1P(1) agonist that does not require S1P-like headgroup interactions" Mol. Pharmacol. 74, 1308-1318 (2008).
Rosen, H., M.G. Sanna, S.M. Cahalan, and P.J. Gonzalez-Cabrera. "Tipping the gatekeeper: S1P regulation of endothelial barrier function" Trends Immunol. 28, 102-107 (2007).
Sanna, M.G., S.K. Wang, P.J. Gonzalez-Cabrera, A. Don, D. Marsolais, M.P. Matheu, S.H. Wei, I. Parker, E.J. Jo, W.C. Cheng, M.D. Cahalan, C.H. Wong, and H. Rosen. "Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P(1) antagonist in vivo" Nat. Chem. Biol. 2, 434-441 (2006).
Wei, S.H., H. Rosen, M.P. Matheu, M.G. Sanna, S.K. Wang, E.J. Jo, C.H. Wong, I. Parker, and M.D. Cahalan. "Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses" Nat. Immunol. 6, 1228-1235 (2005).